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类风湿关节炎患者的淋巴细胞耗竭

Lymphocyte depletion in patients with rheumatoid arthritis.

作者信息

Pearson C M

出版信息

Agents Actions. 1976 Feb;6(1-3):28-31. doi: 10.1007/BF01972182.

DOI:10.1007/BF01972182
PMID:941802
Abstract

Sixteen patients with severe rheumatoid arthritis, marked inflammation of the synonvial membrane and high rheumatoid titer were cannulated by the thoracic duct for a period rangin between 82 up to 100 days. The patients being not under any medication during that time. Quantitative and qualitative analysis of the lymphocytes were performed, as well as responses to mitogens, rheumatoid factor, circulating antibodies and delayed hypersensitivity. By the 14th day nearly all the patients had a partial or almost complete remission of their disease. No complications were observed. These results will be discussed.

摘要

16例患有严重类风湿性关节炎、滑膜明显炎症且类风湿因子滴度高的患者接受了胸导管插管,插管时间为82至100天。在此期间,患者未服用任何药物。对淋巴细胞进行了定量和定性分析,以及对丝裂原、类风湿因子、循环抗体和迟发型超敏反应的反应。到第14天,几乎所有患者的病情都有部分或几乎完全缓解。未观察到并发症。将对这些结果进行讨论。

相似文献

1
Lymphocyte depletion in patients with rheumatoid arthritis.类风湿关节炎患者的淋巴细胞耗竭
Agents Actions. 1976 Feb;6(1-3):28-31. doi: 10.1007/BF01972182.
2
The effect of thoracic duct drainage on lymphocyte dynamics and clinical symptoms in patients with rheumatoid arthritis.胸导管引流对类风湿性关节炎患者淋巴细胞动力学及临床症状的影响。
Arthritis Rheum. 1979 Dec;22(12):1405-12. doi: 10.1002/art.1780221217.
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Lymphocyte involvement in rheumatoid arthritis. Studies during thoracic duct drainage.
Arthritis Rheum. 1977 Jul-Aug;20(6):1249-62. doi: 10.1002/art.1780200614.
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Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse.类风湿关节炎患者接受利妥昔单抗治疗后循环中B淋巴细胞刺激因子水平:与B细胞耗竭、循环抗体及临床复发的关系
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[Rheumatoid arthritis and autoimmune hemolysis: B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease].[类风湿关节炎与自身免疫性溶血:B细胞清除疗法诱导一名类风湿关节炎合并冷凝集素病患者缓解]
Z Rheumatol. 2010 Aug;69(6):557-60. doi: 10.1007/s00393-010-0607-3.
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Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody.用抗CD4单克隆抗体治疗类风湿性关节炎。
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In vivo T cell depletion in rheumatoid arthritis is associated with increased in vitro IgM-rheumatoid factor synthesis.类风湿关节炎患者体内T细胞耗竭与体外IgM类风湿因子合成增加有关。
Clin Immunol Immunopathol. 1993 May;67(2):124-9. doi: 10.1006/clin.1993.1054.
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B lymphocyte depletion therapy with rituximab in rheumatoid arthritis.利妥昔单抗用于类风湿关节炎的B淋巴细胞清除疗法。
Rheum Dis Clin North Am. 2004 May;30(2):393-403, viii. doi: 10.1016/j.rdc.2004.01.006.
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Characterization of recirculating lymphocytes in rheumatoid arthritis patients: selective deficiency of natural killer cells in thoracic duct lymph.类风湿关节炎患者循环淋巴细胞的特征:胸导管淋巴中自然杀伤细胞的选择性缺乏
J Immunol. 1984 Jun;132(6):2883-7.
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A case report: thoracic duct lymphocyte drainage in rheumatoid arthritis.病例报告:类风湿关节炎中的胸导管淋巴细胞引流
Clin Immunol Immunopathol. 1973 Jan;1(2):173-81. doi: 10.1016/0090-1229(73)90017-2.

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Neutropenia and rheumatoid arthritis.中性粒细胞减少症与类风湿关节炎
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