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The genetic reconstruction of BCG as a new immunotherapeutic tool.

作者信息

O'Donnell M A

机构信息

Harvard Medical School, Beth Israel Deaconess Medical Center, Division of Urology, Boston, MA 02215, USA.

出版信息

Trends Biotechnol. 1997 Dec;15(12):512-7. doi: 10.1016/S0167-7799(97)01134-7.

DOI:10.1016/S0167-7799(97)01134-7
PMID:9418306
Abstract

The bacillus of Calmette and Guérin (BCG), long appreciated for its role as a live vaccine for the prevention of tuberculosis, is undergoing a rebirth as a recombinant delivery vehicle for foreign antigens and bioactive proteins. Recombinant BCG causes long-lived specific humoral and cellular immunity and may ultimately prove to be a powerful and cost-effective new weapon against both infectious pathogens and certain cancers.

摘要

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