Kackar R, Srivastava M K, Raizada R B
Pesiticide Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
J Appl Toxicol. 1997 Nov-Dec;17(6):369-75. doi: 10.1002/(sici)1099-1263(199711/12)17:6<369::aid-jat449>3.0.co;2-q.
Mancozeb, an ethylenebisdithiocarbamate (EBDC), has been studied for its effects on rat thyroid. Single oral administration of mancozeb at different concentrations (9600, 12,000, 15,000 and 18,750 mg kg(-1) body wt) has derived the oral LD50 value as 15,000 mg kg(-1) body wt. in male rats. Mancozeb at repeated oral doses of 500, 1000 and 1500 mg kg(-1) day(-1) for periods of 30, 90, 180 and 360 days has produced dose-dependent signs of toxicity and death of animals. The fungicide caused a significant increase in thyroid/body weight ratio and histopathological changes. Reduced levels of thyroid radioiodine ([125]I) uptake, serum protein-bound iodine (PB[125]I), thyroxine (T4) and reduced activity of thyroid peroxidase (TPO) have also been observed after exposure to mancozeb. Thus, mancozeb has been shown to produce marked structural and functional changes in thyroid of rats.
代森锰锌，一种亚乙基双二硫代氨基甲酸盐（EBDC），已针对其对大鼠甲状腺的影响展开研究。以不同浓度（9600、12000、15000和18750毫克/千克体重）单次口服代森锰锌，得出雄性大鼠的口服半数致死剂量（LD50）值为15000毫克/千克体重。以500、1000和1500毫克/千克体重·天−1的重复口服剂量给药30、90、180和360天，会产生剂量依赖性的毒性迹象和动物死亡。该杀菌剂导致甲状腺/体重比显著增加以及组织病理学变化。接触代森锰锌后，还观察到甲状腺放射性碘（[125]I）摄取量、血清蛋白结合碘（PB[125]I）、甲状腺素（T4）水平降低以及甲状腺过氧化物酶（TPO）活性降低。因此，已表明代森锰锌会在大鼠甲状腺中产生明显的结构和功能变化。
