日本人群中的人类白细胞抗原（HLA）抗原
HLA antigens in Japanese populations.
作者信息
Yasuda N, Tsuji K, Aizawa M, Itakura K, Inou T, Matsukura M, Yoshida T, Fukunishi T, Orita K, Nomoto K, Ito M
出版信息
Am J Hum Genet. 1976 Jul;28(4):390-9.
HLA antigens in 841 healthy, unrelated Japanese from nine widely separated geographic localities were studied. The five most common antigens observed in order of decreasing frequency were for the HLA-A locus: HLA-A9, A2, A10, AW32 and A11; and for the HLA-B locus: HLA-'B5' (= HLA-B5+B17), BW40, B12, B14 and B8. The allelic frequency of undetected antigens of the HLA-A locus was .14-.37, and that of the HLA-B locus, .32-.67, indicating that there were serological difficulties in typing for Japanese antigens using antisera from Caucasians. Marked gene frequency clines were observed for HLA-A9 and HLA-A2 from south (Okinawa) to north (Nagoya). Two haplotypes, HLA-A9, B5 and HLA-A10, BW40 were shown to be in linkage disequilibrium in four of the nine subpopulations.
对来自九个地理位置相距甚远的地区的841名健康、无亲缘关系的日本个体的HLA抗原进行了研究。按频率递减顺序观察到的五个最常见抗原，对于HLA - A位点：HLA - A9、A2、A10、AW32和A11；对于HLA - B位点：HLA - 'B5'（= HLA - B5 + B17）、BW40、B12、B14和B8。HLA - A位点未检测到的抗原的等位基因频率为0.14 - 0.37，HLA - B位点的为0.32 - 0.67，这表明使用白种人的抗血清对日本抗原进行分型存在血清学困难。从南（冲绳）到北（名古屋）观察到HLA - A9和HLA - A2存在明显的基因频率渐变群。在九个亚群中的四个中，两种单倍型HLA - A9、B5和HLA - A10、BW40显示出连锁不平衡。
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