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Inhibition of immunoreactive tumor necrosis factor-alpha by a chimeric antibody in patients infected with human immunodeficiency virus type 1.嵌合抗体对感染1型人类免疫缺陷病毒患者免疫反应性肿瘤坏死因子-α的抑制作用
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Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation.沙利度胺通过增强信使核糖核酸降解对肿瘤坏死因子α发挥抑制作用。
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In vitro activity of thalidomide against Mycobacterium avium complex.沙利度胺对鸟分枝杆菌复合群的体外活性。
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Thalidomide inhibits the replication of human immunodeficiency virus type 1.沙利度胺抑制1型人类免疫缺陷病毒的复制。
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The treatment of microsporidial diarrhoea with thalidomide.沙利度胺治疗微孢子虫性腹泻
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沙利度胺在人类免疫缺陷病毒感染患者中的单剂量药代动力学。

Single-dose pharmacokinetics of thalidomide in human immunodeficiency virus-infected patients.

作者信息

Piscitelli S C, Figg W D, Hahn B, Kelly G, Thomas S, Walker R E

机构信息

Department of Pharmacy, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Antimicrob Agents Chemother. 1997 Dec;41(12):2797-9. doi: 10.1128/AAC.41.12.2797.

DOI:10.1128/AAC.41.12.2797
PMID:9420064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164214/
Abstract

The pharmacokinetics of thalidomide in nine human immunodeficiency virus-infected patients were studied. Single doses of thalidomide were well absorbed, with mean peak concentrations (+/- standard deviations) of 1.17 +/- 0.21 and 3.47 +/- 1.14 microg/ml in the 100- and 300-mg dosing groups, respectively, and the mean elimination half-life was approximately 6 h. Adverse effects were mild, with drowsiness being reported for seven of nine patients.

摘要

研究了沙利度胺在9例人类免疫缺陷病毒感染患者中的药代动力学。单剂量沙利度胺吸收良好，100毫克和300毫克给药组的平均峰值浓度（±标准差）分别为1.17±0.21和3.47±1.14微克/毫升，平均消除半衰期约为6小时。不良反应轻微，9例患者中有7例报告有嗜睡症状。