胰岛素样生长因子作为卵泡命运的决定因素。
Insulin-like growth factors as determinants of follicular fate.
作者信息
Adashi E Y
机构信息
Departments of Obstetrics/Gynecology and Physiology, University of Maryland School of Medicine, Baltimore 21201, USA.
出版信息
J Soc Gynecol Investig. 1995 Nov-Dec;2(6):721-6.
OBJECTIVE
To review the English-language literature as it relates to the rat intraovarian insulin-like growth factor (IGF) system, special emphasis being placed on the hypotheses under study.
METHODS
A thorough literature review of the English-language literature.
RESULTS
Current data support the view that intraovarian IGF-I may act as an amplifier of gonadotropin hormonal action. The role of IGF-I as a determinant of follicular fate remains a matter of study.
CONCLUSIONS
The intraovarian IGF-I system may play a central role in ovarian physiology by amplifying gonadotropin hormonal action and, possibly, by playing a role in determining follicular fate.
目的
回顾与大鼠卵巢内胰岛素样生长因子（IGF）系统相关的英文文献，特别关注正在研究的假说。
方法
对英文文献进行全面的文献综述。
结果
目前的数据支持卵巢内IGF-I可能作为促性腺激素作用放大器的观点。IGF-I作为卵泡命运决定因素的作用仍有待研究。
结论
卵巢内IGF-I系统可能通过放大促性腺激素的作用，并可能在决定卵泡命运方面发挥作用，从而在卵巢生理学中发挥核心作用。
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