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人类运动皮层手部区域的躯体定位。一项高分辨率功能磁共振成像研究。

Somatotopy in the human motor cortex hand area. A high-resolution functional MRI study.

作者信息

Kleinschmidt A, Nitschke M F, Frahm J

机构信息

Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.

出版信息

Eur J Neurosci. 1997 Oct;9(10):2178-86. doi: 10.1111/j.1460-9568.1997.tb01384.x.

Abstract

Fine-scale somatotopic encoding in brain areas devoted to sensorimotor processing has recently been questioned by functional neuroimaging studies which suggested its absence within the hand area of the human primary motor cortex. We re-examined this issue by addressing somatotopy both in terms of functional segregation and of cortical response preference using oxygenation-sensitive magnetic resonance imaging at high spatial resolution. In a first step, spatial representations of self-paced isolated finger movements were mapped by using motor rest as a control state. A subsequent experimental design studied the predominance of individual finger movements by using contrasting finger movements as the control task. While the first approach confirmed previous reports of extensive overlap in spatial representations, the second approach revealed foci of differential activation which displayed an orderly mediolateral progression in accordance with the classical cortical motor homunculus. We conclude that somatotopy within the hand area of the primary motor cortex does not present as qualitative functional segregation but as quantitative predominance of certain movement or digit representation embedded in an overall joint hand area.

摘要

近期,功能神经影像学研究对致力于感觉运动处理的脑区中精细的躯体感觉定位编码提出了质疑,这些研究表明在人类初级运动皮层的手部区域不存在这种编码。我们通过使用高空间分辨率的氧合敏感磁共振成像,从功能分离和皮层反应偏好两方面来研究躯体感觉定位,从而重新审视了这个问题。第一步,以运动静息作为对照状态,绘制自我节奏孤立手指运动的空间表征。随后的实验设计通过使用对比手指运动作为对照任务,研究单个手指运动的优势。虽然第一种方法证实了先前关于空间表征广泛重叠的报道,但第二种方法揭示了差异激活的焦点,这些焦点根据经典的皮层运动小人像显示出有序的中外侧进展。我们得出结论,初级运动皮层手部区域内的躯体感觉定位并非表现为定性的功能分离,而是表现为嵌入在整体联合手部区域中的某些运动或手指表征的定量优势。

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