Hung K Y, Ho C Y, Kuo Y M, Lee S H, Hseih S J, Yang C S, Peng C J, Wu D J, Hung J T, Chen P Y, Chen J S, Chen W Y
Department of Internal Medicine, National Taiwan University Hospital, Taipei, ROC.
Int J Artif Organs. 1997 Oct;20(10):553-6.
Hemodialysis therapy and the aging process have been reported to interfere with the trace element (TE) status in the body. This multicenter collaborative study on blood levels of TE in geriatric hemodialysis (HD) patients was carried out with an aim to clarify the impact of the aging process and HD therapy on the TE status in such patients.
One hundred and fifty-one HD patients (65 male, 86 female), all aged over 60 (68.2+/-3.86 y), and 112 elderly controls (58 male, 54 female) with a mean age of 67.5+/-3.03 were enrolled. All patients underwent standard HD for at least 6 months. The artificial kidneys used were hollow-fiber dialyzers of cellulose membranes. Water used for HD was prepared by reverse osmosis. Blood was collected in the morning prior to dialysis and after fasting. Atomic absorption spectrophotometry was applied to measure blood levels of Pb, Cd and Hg as well as plasma levels of Cu, Zn and Al. Data are presented as mean +/- SEM. Student's t-test and linear regression were applied for statistics.
Our geriatric chronic HD patients showed a marked elevation of blood Al and decreased plasma Zn concentrations. The blood levels of Cu, Cd, Pb and Hg were within normal limits. The blood concentrations of Al, Cu and Pb were significantly higher in HD patients than in the normal elderly controls, whereas Cd and Hg were similar in both groups, and Zn were lower in HD patients. Plasma Zn value decreased as dialysis duration increased, however there was a reversely linear correlation between plasma Zn and age.
This data reported can be regarded as a starting point and may serve as an insight to further studies on TE imbalances in geriatric and chronic HD populations.
据报道，血液透析治疗与衰老过程会干扰体内微量元素（TE）状况。开展这项关于老年血液透析（HD）患者血液中TE水平的多中心协作研究，旨在阐明衰老过程和HD治疗对这类患者TE状况的影响。
纳入151例HD患者（男性65例，女性86例），年龄均超过60岁（68.2±3.86岁），以及112例老年对照者（男性58例，女性54例），平均年龄为67.5±3.03岁。所有患者均接受标准HD治疗至少6个月。使用的人工肾为纤维素膜中空纤维透析器。HD用水采用反渗透法制备。在透析前早晨空腹时采集血液。采用原子吸收分光光度法测量血液中铅、镉和汞的水平以及血浆中铜、锌和铝的水平。数据以均值±标准误表示。采用学生t检验和线性回归进行统计学分析。
我们的老年慢性HD患者血液铝水平显著升高，血浆锌浓度降低。铜、镉、铅和汞的血液水平在正常范围内。HD患者血液中铝、铜和铅的浓度显著高于正常老年对照者，而镉和汞在两组中相似，HD患者的锌水平较低。血浆锌值随透析时间延长而降低，然而血浆锌与年龄呈反向线性相关。
所报道的数据可被视为一个起点，可能有助于深入研究老年和慢性HD人群中的TE失衡情况。
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