暴露于别嘌醇和氧嘌呤醇的人淋巴细胞中无染色体损伤。
Absence of chromosome damage in human lymphocytes exposed to allopurinol and oxipurinol.
作者信息
Stevenson A C, Silcock S R, Scott J T
出版信息
Ann Rheum Dis. 1976 Apr;35(2):143-7. doi: 10.1136/ard.35.2.143.
The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 patients receiving allopurinol and one receiving oxipurinol were examined for the presence of chromatid aberrations during metaphase, and lymphocytes from untreated subjects were similarly studied during in vitro exposure to the drugs. The low frequency of aberrations observed was well within normal limits, and it is concluded that allopurinol and oxipurinol have no deleterious effects on chromosome structure.
本文综述了关于嘌呤类似物别嘌醇和氧嘌呤醇未掺入核酸的生化证据。已开展细胞学实验，以研究人类淋巴细胞暴露于这些药物是否可能导致染色体损伤。检查了19名接受别嘌醇治疗的患者及1名接受氧嘌呤醇治疗患者的淋巴细胞在中期时的染色单体畸变情况，并对未接受治疗的受试者的淋巴细胞在体外暴露于这些药物期间进行了类似研究。观察到的畸变频率很低，完全在正常范围内，因此得出结论，别嘌醇和氧嘌呤醇对染色体结构没有有害影响。
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