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2-[4-(4-碘苯基)-1-哌嗪基甲基]-1,3,4-恶二唑的合成及其在羰基化合物间接碘化中的潜在应用。

Synthesis of 2-[4-(4-iodophenyl)-1-piperazinylmethyl]-1,3,4-oxadiazole and its potential application in the indirect iodination of carbonyl compounds.

作者信息

Hassan M A, Shabsoug B M

机构信息

Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

出版信息

Acta Pharm Hung. 1997 Nov;67(6):263-6.

PMID:9423297
Abstract

The synthesis of 2-[4-(4-iodophenyl)-1-piperazinylmethyl]- 1,3,4-oxadiazole is discussed. Hydrolysis of the oxadiazole followed by condensation with 3 beta-hydroxy-5-androsten-17-one gave the hydrazone. This synthetic sequence could be applied for the indirect iodination/radioiodination of ketosteroids.

摘要

讨论了2-[4-(4-碘苯基)-1-哌嗪基甲基]-1,3,4-恶二唑的合成。恶二唑水解后与3β-羟基-5-雄甾烯-17-酮缩合得到腙。该合成序列可用于酮甾体的间接碘化/放射性碘化。

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