Kondo H, Shinbo I
Department of Medicine, Shimizu Kosei Hospital.
Rinsho Ketsueki. 1997 Nov;38(11):1234-7.
A 62-year-old man was found to have myelodysplastic syndrome (MDS) and gastric cancer. Serum studies revealed hypogammaglobulinemia, and positive reactions to rheumatoid test and anti-nuclear antibody. Chromosomal analysis of the bone marrow revealed deletions of No. 5 and 7 chromosomes and that of the stomach showed complex abnormalities. It may be hypothesized that an initial event which selects a clone of stem cells could manifest with this sort of immunological abnormalities. Subsequent deranged immunosurveillance may be responsible for the increased risk of cancer. Alternatively an increased chromosomal instability which seems to be associated with immunodeficiencies might be responsible for cancer development.
一名62岁男性被诊断患有骨髓增生异常综合征（MDS）和胃癌。血清学检查显示低丙种球蛋白血症，类风湿因子和抗核抗体呈阳性反应。骨髓染色体分析显示5号和7号染色体缺失，胃部染色体分析显示复杂异常。可以推测，选择干细胞克隆的初始事件可能表现为这种免疫异常。随后紊乱的免疫监视可能是癌症风险增加的原因。或者，似乎与免疫缺陷相关的染色体不稳定性增加可能是癌症发生的原因。
