Lakshminarayanan V, Bailey J E, Enoch J M
School of Optometry and Department of Physics and Astronomy, University of Missouri-St. Louis 63121-4499, USA.
Optom Vis Sci. 1997 Dec;74(12):1011-8. doi: 10.1097/00006324-199712000-00022.
We investigated whether Stiles-Crawford (SCE) functions, a measure of photoreceptor orientation and alignment, are disturbed in patients with nasal fundus ectasia (tilted disc; Fuch's coloboma without apparent pupillary involvement).
SCE functions were obtained in three observers with nasal fundus ectasia, using psychophysical methods.
In all cases, disruption of photoreceptor alignment can be inferred. Results include location of the SCE peaks outside the pupil in the direction of the lesion, differential alignment, and reduction of the magnitude of SCE at various retinal loci (reduced curvature or p factor). Additional results obtained with the selective adaptation technique imply that receptor disarray (splaying) may be responsible for loss of retinal directional sensitivity.
From these results, it may be surmised that mechanical tractional forces can play a major role in defining photoreceptor orientation in the retina. Inferred anomalous photoreceptor alignment has heretofore not been specifically linked with Fuch's coloboma/tilted disc syndrome.
我们研究了作为光感受器定向和排列指标的斯泰尔斯 - 克劳福德（SCE）功能在鼻侧眼底扩张（倾斜视盘；无明显瞳孔受累的富克斯缺损）患者中是否受到干扰。
采用心理物理学方法，在三名鼻侧眼底扩张患者中获取SCE功能。
在所有病例中，均可推断光感受器排列受到破坏。结果包括SCE峰值在瞳孔外朝着病变方向的位置、差异排列以及在不同视网膜位点处SCE幅度的降低（曲率降低或p因子降低）。通过选择性适应技术获得的其他结果表明，感受器紊乱（散开）可能是视网膜方向敏感性丧失的原因。
从这些结果可以推测，机械牵拉力在确定视网膜中光感受器的方向方面可能起主要作用。迄今为止，推断出的异常光感受器排列尚未与富克斯缺损/倾斜视盘综合征明确相关。
