Dzienis H, Pruszyński K, Ladny J R, Puchalski Z, Dadan J
Kliniki Chirurgii Ogólnej Akademii Medycznej w Białymstoku.
Wiad Lek. 1997;50 Suppl 1 Pt 2:354-7.
Determinations of collagen in specimens of duodenal mucosa taken from 15 patients operated on because of duodenal ulcer with pyloric stenosis were performed. In the ulcer and surrounding tissue, total collagen values were significantly increased when compared with the results in unchanged wall of the duodenum. Collagen polymorphism study showed considerably higher percentage of type I and decreased type III in the ulceration than in control duodenal mucosa. In conclusion, extracellular components of connective tissue may play a role in the formation and course of duodenal ulcer disease.
对15例因十二指肠溃疡伴幽门狭窄而接受手术的患者所取十二指肠黏膜标本中的胶原蛋白进行了测定。在溃疡及周围组织中，与十二指肠未病变壁的结果相比，总胶原蛋白值显著增加。胶原蛋白多态性研究显示，溃疡处I型胶原蛋白的比例明显高于对照十二指肠黏膜，而III型胶原蛋白的比例则降低。总之，结缔组织的细胞外成分可能在十二指肠溃疡疾病的形成和发展过程中发挥作用。
