Dale T C
Developmental Biology Team, Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, U.K.
Biochem J. 1998 Jan 15;329 ( Pt 2)(Pt 2):209-23. doi: 10.1042/bj3290209.
The Wnt genes encode a large family of secreted polypeptides that mediate cell-cell communication in diverse developmental processes. The loss or inappropriate activation of Wnt expression has been shown to alter cell fate, morphogenesis and mitogenesis. Recent progress has identified Wnt receptors and components of an intracellular signalling pathway that mediate Wnt-dependent transcription. This review will highlight this 'core' Wnt signal-transduction pathway, but also aims to reveal the potential diversity of Wnt signalling targets. Particular attention will be paid to the overlap between developmental biology and oncogenesis, since recent progress shows Wnt signalling forms a paradigm for an interdisciplinary approach.
Wnt基因编码一大类分泌型多肽，它们在多种发育过程中介导细胞间通讯。已表明Wnt表达的缺失或不适当激活会改变细胞命运、形态发生和有丝分裂。最近的进展已经确定了Wnt受体和细胞内信号通路的组成部分，这些成分介导依赖Wnt的转录。本综述将重点介绍这条“核心”Wnt信号转导途径，但同时也旨在揭示Wnt信号靶标的潜在多样性。由于最近的进展表明Wnt信号形成了一种跨学科方法的范例，因此将特别关注发育生物学与肿瘤发生之间的重叠。
