回肠旁路术对白卡诺鸽固醇平衡和血浆胆固醇的影响。

The effect of ileal bypass on sterol balance and plasma cholesterol in the White Carneau pigeon.

作者信息

Flynn K J, Schumacher J F, Subbiah M T, Kottke B A

出版信息

Atherosclerosis. 1976 Jul-Aug;24(1-2):75-80. doi: 10.1016/0021-9150(76)90065-4.

Abstract

The effect of ileal bypass on steady-state sterol balance and plasma cholesterol was studied in sham operated (SO) and ileal bypass (IB) White Carneau pigeons 6 months (Group I) and 18 months (Group II) after surgery while fed their usual cholesterol-free diet. Unlike what has been noted in other animals, the bile acid (BA) and neutral sterol (NS) excretion (mg/kg per day) in IB was not statistically different from that in SO. Group I: BA, 40.2 (SO) vs 39.0 (IB); NS, 13.3 (SO) vs 17.3 (IB). Group II: BA, 55.7 (SO) vs 54.1 (IB); NS, 9.57 (SO) vs 8.84 (IB). IB pigeons had only slightly lower plasma cholesterol levels (postoperative) than SO pigeons. Group I, 329 (SO) vs 271 (IB) mg/dl (P less than 0.05); Group II, 374 (SO) vs 312 (IB) mg/dl. This study indicates that the response to ileal bypass by White Carneau pigeons in terms of cholesterol excretion and plasma cholesterol changes is different than what has been observed in other species.

摘要

在术后6个月（第一组）和18个月（第二组）的假手术（SO）和回肠旁路术（IB）白卡诺鸽中，研究了回肠旁路术对稳态固醇平衡和血浆胆固醇的影响，这些鸽子喂食其通常的无胆固醇饮食。与在其他动物中所观察到的情况不同，IB组的胆汁酸（BA）和中性固醇（NS）排泄量（毫克/千克/天）与SO组相比无统计学差异。第一组：BA，40.2（SO）对39.0（IB）；NS，13.3（SO）对17.3（IB）。第二组：BA，55.7（SO）对54.1（IB）；NS，9.57（SO）对8.84（IB）。IB鸽的血浆胆固醇水平（术后）仅略低于SO鸽。第一组，329（SO）对271（IB）毫克/分升（P小于0.05）；第二组，374（SO）对312（IB）毫克/分升。本研究表明，白卡诺鸽对回肠旁路术在胆固醇排泄和血浆胆固醇变化方面的反应与在其他物种中所观察到的不同。