Doonan J, Fobert P
John Innes Centre, Norwich, UK.
Curr Opin Cell Biol. 1997 Dec;9(6):824-30. doi: 10.1016/s0955-0674(97)80083-x.
Cell division is highly regulated, both spatially and temporally, during plant development. Recent evidence implicates cyclin-dependent kinases (cdks) and their associated proteins as the principal temporal regulators of cell division. It is now known that plants contain an extended family of cdks, some of which appear to be unique to this group. Positive rate-limiting regulators of cell proliferation and growth include mitotic or B-type cyclins whose transcription is restricted to the G2 and M phases. Current research suggests that MYB-related transcription factors may be responsible for this restriction. Cdk-interacting proteins, such as cdk inhibitors and suc1 homologues, have been isolated using yeast two-hybrid approaches.
在植物发育过程中，细胞分裂在空间和时间上都受到高度调控。最近的证据表明，细胞周期蛋白依赖性激酶（CDKs）及其相关蛋白是细胞分裂的主要时间调节因子。现在已知植物含有一个扩展的CDK家族，其中一些似乎是该类群所特有的。细胞增殖和生长的正向限速调节因子包括有丝分裂或B型细胞周期蛋白，其转录仅限于G2期和M期。目前的研究表明，MYB相关转录因子可能负责这种限制。已经使用酵母双杂交方法分离出了与CDK相互作用的蛋白，如CDK抑制剂和suc1同源物。
