Karwowska-Polecka W, Kułakowska A, Wiśniewski K, Braszko J J
Department of Pharmacology, Medical Academy of Białystok, Poland.
Pharmacol Res. 1997 Oct;36(4):275-83. doi: 10.1006/phrs.1997.0239.
We have previously shown that angiotensin II(3-7) [Ang II(3-7)] stimulates behavioural activity of rats similar to angiotensin II (Ang II). The involvement of AT1 angiotensin receptors in stimulating the behavioural activity of rats, using their selective ligand losartan (DUP 753), was examined. Ang II(3-7), given intracerebroventricularly (i.c.v.) at a dose of 1 nmol, significantly enhanced recall of a passive avoidance behaviour, object recognition, learning of conditioned avoidance responses (CARs) and apomorphine (1 mg kg-1, i.p.) stereotypy. Losartan (1 microgram, i.c.v.) did not alter any of the behaviours except for that measuring anxiety which was diminished both, in peptide treated and in control rats. On the other hand, losartan abolished Ang II(3-7) facilitation of recall of the passive avoidance, object recognition and the increase in apomorphine stereotypy. Losartan did not influence the increased rate of CARs acquisition after the peptide. None of the treatments significantly changed locomotor activity estimated in an open field. These data point to some involvement of AT1 angiotensin receptors in the behavioural activity of Ang II(3-7).
我们之前已经表明，血管紧张素II(3 - 7)[Ang II(3 - 7)]刺激大鼠的行为活动，其效果与血管紧张素II(Ang II)相似。使用其选择性配体氯沙坦（DUP 753），研究了AT1血管紧张素受体在刺激大鼠行为活动中的作用。以1 nmol的剂量脑室内注射（i.c.v.）Ang II(3 - 7)，显著增强了被动回避行为的记忆、物体识别、条件性回避反应（CARs）的学习以及阿扑吗啡（1 mg kg-1，腹腔注射）引起的刻板行为。氯沙坦（脑室内注射1微克）除了降低肽处理组和对照组大鼠的焦虑测量值外，未改变任何行为。另一方面，氯沙坦消除了Ang II(3 - 7)对被动回避记忆、物体识别的促进作用以及阿扑吗啡刻板行为的增加。氯沙坦不影响肽处理后CARs获得率的增加。没有任何一种处理显著改变在旷场实验中估计的运动活动。这些数据表明AT1血管紧张素受体在Ang II(3 - 7)的行为活动中发挥了一定作用。
