生发中心反应期间对B细胞抗原特异性进行三重检查。
Triple check for antigen specificity of B cells during germinal centre reactions.
作者信息
Lindhout E, Koopman G, Pals S T, de Groot C
机构信息
Dept of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands.
出版信息
Immunol Today. 1997 Dec;18(12):573-7. doi: 10.1016/s0167-5699(97)01160-2.
Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differentiation of B cells.
生发反应期间免疫球蛋白可变基因的体细胞超突变可能会使具有不良（如自身反应性）特异性的B细胞克隆得以扩增。在此，恩斯特·林德胡特及其同事提出了三个抗原特异性检查点，这些检查点通过调节B细胞的激活、选择和进一步分化来确保活化B细胞维持适当的抗原特异性。
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