Heistad D D, Marcus M L
Stroke. 1976 May-Jun;7(3):239-43. doi: 10.1161/01.str.7.3.239.
The concept that reflex control of cerebral vessels is unimportant has been challenged by recent studies which suggest that carotid baroreceptors have an important role in regulation of cerebral blood flow (CBF). In this study we have tested the hypothesis that arterial baroreceptors contribute to regulation of total or regional CBF. CBF was measured in anesthetized dogs with 15 mu microspheres. Stimulation of carotid baroreceptors, by raising carotid sinus pressure, did not alter or redistribute cerebral flow. Responses to baroreceptor stimulation were intact, as manifested by vasodilation in skeletal muscle. CBF decreased during systemic hypocapnia and increased during hypercapnia, which indicates that failure of cerebral flow to change during baroreceptor stimulation was not due to unresponsiveness of cerebral vessels. During hypercapnia, baroreceptor stimulation also failed to alter CBF. In other studies CBF was measured during increases in systemic arterial pressure, before and after denervation of arterial baroreceptors. Increases in arterial pressure did not increase CBF either before or after denervation of baroreceptors. We conclude that baroreceptor stimulation does not alter total or regional CBF and that baroreceptors do not regulate cerebral flow during systemic hypertension.
脑血管反射控制不重要这一概念已受到近期研究的挑战，这些研究表明颈动脉压力感受器在脑血流量（CBF）调节中起重要作用。在本研究中，我们检验了动脉压力感受器有助于调节总脑血流量或局部脑血流量的假说。使用15μm微球在麻醉犬中测量脑血流量。通过升高颈动脉窦压力刺激颈动脉压力感受器，并未改变或重新分配脑血流。对压力感受器刺激的反应是完整的，如骨骼肌血管舒张所示。在全身性低碳酸血症期间脑血流量减少，在高碳酸血症期间增加，这表明在压力感受器刺激期间脑血流未能改变并非由于脑血管无反应性。在高碳酸血症期间，压力感受器刺激也未能改变脑血流量。在其他研究中，在全身性动脉压升高期间以及动脉压力感受器去神经前后测量脑血流量。在压力感受器去神经前后，动脉压升高均未增加脑血流量。我们得出结论，压力感受器刺激不会改变总脑血流量或局部脑血流量，并且在全身性高血压期间压力感受器不调节脑血流。
