Cho S B, Miyaji F, Kokubo T, Nakamura T
Department of Material Chemistry, Faculty of Engineering, Kyoto University, Japan.
Biomaterials. 1997 Nov;18(22):1479-85. doi: 10.1016/s0142-9612(97)00084-7.
Glass-ceramic A-W(Al), which was prepared by heat treatment of a MgO-CaO-SiO2-P2O5-Al2O3 glass to precipitate crystalline apatite and wollastonite, shows a higher mechanical strength than glass-ceramic A-W, which was prepared by heat treatment of a MgO-CaO-SiO2-P2O5 glass to precipitate the same types of crystalline phases. The former, however, does not show bone-bonding ability, i.e. bioactivity, whereas the latter shows it. In the present study, in order to induce bioactivity of glass-ceramic A-W(Al), it was treated with HCl or NaOH solutions with different concentrations, and its bioactivity was evaluated by examining the apatite formation on its surface in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma. When the glass-ceramic A-W(Al) was pretreated with HCl aqueous solutions with concentrations over 0.1 M, it formed the bone-like apatite on its surface in SBF. This was attributed to the formation of a hydrated silica on its surface by the HCl treatment.
通过对MgO-CaO-SiO₂-P₂O₅-Al₂O₃玻璃进行热处理以沉淀出结晶磷灰石和硅灰石而制备的玻璃陶瓷A-W(Al)，其机械强度高于通过对MgO-CaO-SiO₂-P₂O₅玻璃进行热处理以沉淀出相同类型结晶相而制备的玻璃陶瓷A-W。然而，前者不具备骨结合能力，即生物活性，而后者具备。在本研究中，为了诱导玻璃陶瓷A-W(Al)的生物活性，用不同浓度的HCl或NaOH溶液对其进行处理，并通过检测其在离子浓度与人类血浆几乎相等的模拟体液（SBF）中表面磷灰石的形成来评估其生物活性。当玻璃陶瓷A-W(Al)用浓度超过0.1M的HCl水溶液预处理时，它在SBF中其表面形成了类骨磷灰石。这归因于HCl处理在其表面形成了水合二氧化硅。
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