酸蚀对3CaO.P2O5-CaO.SiO2-CaO.MgO.2SiO2系统微晶玻璃体外生物活性的作用

Role of acid attack in the in vitro bioactivity of a glass-ceramic of the 3CaO.P2O5-CaO.SiO2-CaO.MgO.2SiO2 system.

作者信息

Roman J, Salinas A J, Vallet-Regi M, Oliveira J M, Correia R N, Fernandes M H

机构信息

Department of Quimica Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.

出版信息

Biomaterials. 2001 Jul;22(14):2013-9. doi: 10.1016/s0142-9612(00)00387-2.

DOI:10.1016/s0142-9612(00)00387-2

PMID:11426879

Abstract

A non-bioactive glass-ceramic (GC13) that contains hydroxyapatite (Ca5(PO4)3OH), diopside (CaMg(SiO3)2) and althausite (Mg2 PO4OH) as crystalline phases has been obtained by thermal treatment of a parent bioactive glass (G13) of nominal composition (wt%) 40.0 CaO-34.5 SiO2-16.5 P2O5-8.5 MgO-0.5CaF2. To induce bioactivity, GC13 was chemically treated with 1 M HCl for different periods of time. After chemical etching the in vitro studies showed formation of an apatite-like surface layer. In this article the influence of etching time both on the surface composition of the glass-ceramic and on the growth rate of the apatite layer is studied. It is concluded that the presence of hydroxyapatite in the glass-ceramic, associated to microstructural fluctuations, can favour apatite deposition in vitro.

摘要

一种非生物活性微晶玻璃（GC13），其结晶相包含羟基磷灰石（Ca5(PO4)3OH）、透辉石（CaMg(SiO3)2）和磷铝石（Mg2PO4OH），通过对名义成分为（重量百分比）40.0 CaO - 34.5 SiO2 - 16.5 P2O5 - 8.5 MgO - 0.5CaF2的母体生物活性玻璃（G13）进行热处理而制得。为诱导生物活性，GC13用1 M HCl进行了不同时长的化学处理。化学蚀刻后，体外研究显示形成了类似磷灰石的表面层。本文研究了蚀刻时间对微晶玻璃表面组成以及磷灰石层生长速率的影响。得出的结论是，微晶玻璃中羟基磷灰石的存在，与微观结构波动相关，可促进体外磷灰石沉积。