Means R T
Hematology/Oncology Division, University of Cincinnati College of Medicine, OH, USA.
Cytokines Cell Mol Ther. 1997 Sep;3(3):179-86.
The anaemia that is a common complication of human immunodeficiency virus (HIV) infection bears many similarities to the anaemia of chronic disease. These similarities include an impaired erythropoietin (EPO) response to anaemia, reduced concentrations of marrow progenitors giving rise to erythroid colonies, abnormalities of reticuloendothelial iron metabolism, and correction of anaemia with recombinant human EPO. A model has been developed in which the pathophysiologic processes producing the anaemia of chronic disease may be attributed to actions of the cytokines that mediate the immune response, such as interleukin-1, tumor necrosis factor and the interferons. These cytokines are also implicated in HIV-related anaemia. In this review, the applicability of this cytokine-mediated anaemia model to the anaemia of HIV infection is explored.
贫血是人类免疫缺陷病毒（HIV）感染常见的并发症，与慢性病贫血有许多相似之处。这些相似点包括促红细胞生成素（EPO）对贫血的反应受损、产生红系集落的骨髓祖细胞浓度降低、网状内皮铁代谢异常，以及重组人促红细胞生成素可纠正贫血。已建立了一个模型，其中产生慢性病贫血的病理生理过程可能归因于介导免疫反应的细胞因子的作用，如白细胞介素-1、肿瘤坏死因子和干扰素。这些细胞因子也与HIV相关贫血有关。在这篇综述中，探讨了这种细胞因子介导的贫血模型对HIV感染性贫血的适用性。
