患有痤疮的女性的睾酮浓度与月经过少

Testosterone concentrations and oligomenorrhea in women with acne.

作者信息

Hasinski S, Telang G H, Rose L I, Pollock J L, Spielvogel R L, Miller J L

机构信息

Department of Medicine, Allegheny University of Health Science, Philadelphia, Pennsylvania, USA.

出版信息

Int J Dermatol. 1997 Nov;36(11):845-7. doi: 10.1046/j.1365-4362.1997.00222.x.

DOI:10.1046/j.1365-4362.1997.00222.x

PMID:9427077

Abstract

BACKGROUND

Androgen excess is frequently associated with oligomenorrhea as well as acne. Oligomenorrhea in hirsute women has been demonstrated to be associated with higher active testosterone levels than found in eumenorrheic hirsute women. This study was designed to evaluate whether similar findings are present in women with acne. Forty-four consecutive women with acne were evaluated by measuring their levels of total testosterone, biologically active testosterone, and free testosterone. The women with oligomenorrhea and acne had significantly higher levels of biologically active testosterone than those with eumenorrhea and acne. This implies that biological active testosterone should be measured in oligomenorrheic women with acne and, if elevated, consideration should be given to antiandrogen therapy.

METHODS

Data were collected from 44 consecutive Caucasian women aged 14 to 38 years. The patients were separated into two groups based on menstrual history. Group 1 had regular menses, and group 2 had oligomenorrhea, defined as menstrual intervals of greater than 36 days. All patients had blood samples drawn on their initial office visit, regardless of the phase of the menstrual cycle, and the levels of total testosterone (TT), biologically active testosterone (BT), and free testosterone (FT) were obtained.

RESULTS

The serum TT level was 87 +/- 41.3 ng/dL (range, 31-150 ng/dL) in oligomenorrheic women and 56 +/- 27.5 ng/dL (range 8-107 ng/dL) in eumenorrheic women. There was no statistically significant difference. The serum BT level in oligomenorrheic women was 33 +/- 16.9 ng/dL (range, 11-51 ng/dL) and in eumenorrheic women 19 +/- 13.6 ng/dL (range, 11-51 ng/dL). This difference was statistically significant (p < 0.05). The serum FT level in oligomenorrheic women was 18 +/- 9.4 pg/mL (range, 1-29 pg/mL) and in eumenorrheic women 10 +/- 7.1 pg/mL (range, 1-32 pg/mL). This difference was not statistically significant (Table 1).

CONCLUSIONS

Women with acne and oligomenorrhea, similar to women with hirsutism and oligomenorrhea, have higher levels of biologically active testosterone than those with normal menses.

摘要

背景

雄激素过多常与月经过少以及痤疮相关。多毛女性的月经过少已被证明与活性睾酮水平高于月经正常的多毛女性有关。本研究旨在评估痤疮女性中是否存在类似的发现。通过测量44例连续的痤疮女性的总睾酮、生物活性睾酮和游离睾酮水平进行评估。月经过少且患有痤疮的女性其生物活性睾酮水平显著高于月经正常且患有痤疮的女性。这意味着对于月经过少且患有痤疮的女性应检测生物活性睾酮水平，若其升高，则应考虑抗雄激素治疗。

方法

收集44例年龄在14至38岁之间的连续白种女性的数据。根据月经史将患者分为两组。第1组月经规律，第2组月经过少，定义为月经周期间隔大于36天。所有患者在初次就诊时均采集血样，无论处于月经周期的哪个阶段，均测定总睾酮（TT）、生物活性睾酮（BT）和游离睾酮（FT）水平。

结果

月经过少女性的血清TT水平为87±41.3 ng/dL（范围31 - 150 ng/dL），月经正常女性为56±27.5 ng/dL（范围8 - 107 ng/dL）。差异无统计学意义。月经过少女性的血清BT水平为33±16.9 ng/dL（范围11 - 51 ng/dL），月经正常女性为19±13.6 ng/dL（范围11 - 51 ng/dL）。差异具有统计学意义（p < 0.05）。月经过少女性的血清FT水平为18±9.4 pg/mL（范围1 - 29 pg/mL），月经正常女性为10±7.1 pg/mL（范围1 - 32 pg/mL）。差异无统计学意义（表1）。