血清p53抗体在肺鳞状细胞癌中的预后意义
Prognostic significance of serum p53 antibodies in squamous cell carcinoma of the lung.
作者信息
Komiya T, Hirashima T, Takada M, Masuda N, Yasumitsu T, Nakagawa K, Hosono Y, Kikui M, Tsuji S, Fukuoka M, Kawase I
机构信息
Second Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Osaka, Japan.
出版信息
Anticancer Res. 1997 Sep-Oct;17(5B):3721-4.
BACKGROUND
The prognostic significance of serum p53-Abs positivity for non-small cell lung cancer (NSCLC) is still unknown.
PATIENTS AND METHODS
To determine the prognostic value of serum p53-Abs status, we determined serum p53-Abs and immunohistochemistry in 140 patients with stage I-IIIA NSCLC.
RESULTS
p53-Abs were detected in 12.1% of all patients and in 17.6% of those with squamous cell carcinoma (SCC). Neither p53-Abs nor p53 overexpression alone was correlated with survival for all patients. When these factors were combined for SCC, seronegative patients with tumors overexpressing p53 survived significantly longer than did those with p53-Abs or p53-nonexpressing tumors. In multivariate analysis, p53-Abs status and p53 overexpression were independent prognostic factors for SCC (p = 0.0337).
CONCLUSIONS
These findings suggest that the combination of p53Abs seropositivity and p53 overexpression may be a prognostic factor for SCC.
背景
血清p53抗体阳性对非小细胞肺癌（NSCLC）的预后意义仍不明确。
患者与方法
为确定血清p53抗体状态的预后价值，我们对140例Ⅰ-ⅢA期NSCLC患者进行了血清p53抗体检测及免疫组化分析。
结果
所有患者中12.1%检测到p53抗体，鳞状细胞癌（SCC）患者中17.6%检测到p53抗体。单独的p53抗体或p53过表达均与所有患者的生存无关。对于SCC患者，当将这些因素综合考虑时，p53过表达但血清阴性的患者比p53抗体阳性或p53未表达肿瘤的患者生存时间显著更长。多因素分析显示，p53抗体状态和p53过表达是SCC的独立预后因素（p = 0.0337）。
结论
这些发现提示p53抗体血清阳性与p53过表达相结合可能是SCC的一个预后因素。
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