人绒毛膜对安定和哌替啶的通透性。
Permeability of human chorion laeve to diazepam and meperidine.
作者信息
Seeds A E, Stolee A, Eichhorst B C
出版信息
Obstet Gynecol. 1976 Jan;47(1):28-30.
PMID:942777
Abstract
In vitro placental permeability to diazepam (Valium) and meperidine (Demerol) in excess of that measured for antipyrine, suggest that these compounds will diffuse across placental tissue in vivo at a maximal or perfusion-limited rate. Such findings correspond to the high fetal blood levels reported for these substances following maternal administration and indicate that these lipid-soluble analgesics cross this tissue by transcellular as well as extracellular pathways.
摘要
体外实验显示，胎盘对安定（Valium）和哌替啶（Demerol）的通透性超过了对安替比林的测量值，这表明这些化合物在体内将以最大或灌注受限的速率扩散穿过胎盘组织。这些发现与母体给药后这些物质在胎儿血液中报告的高浓度相对应，并表明这些脂溶性镇痛药通过跨细胞和细胞外途径穿过该组织。
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