Lifrak I L, Lev R, Loud A V
Pediatr Res. 1976 Feb;10(2):100-2. doi: 10.1203/00006450-197602000-00005.
Twenty milligrams of lactose were injected into the amniotic sacs of fetuses in one uterine horn and 20 mg glucose were injected into the amniotic sacs of fetuses in the opposite uterine horn of six rats on days 17-19 of pregnancy. Two or 3 days later the pregnant animals were killed and segments of jejunum obtained from their fetuses were homogenized in water. Assays for lactase and protein determinations were performed on these homogenates. Lactase values were significantly higher in the lactose-injected group than in fetuses receiving glucose (Table 2), P less than 0.0005. Thus, fetal intestinal lactase activity can be increased by exposure to the substrate lactose during late fetal life.
在妊娠第17至19天，给6只大鼠一侧子宫角内的胎儿羊膜囊注射20毫克乳糖，给另一侧子宫角内的胎儿羊膜囊注射20毫克葡萄糖。两或三天后，处死妊娠动物，取其胎儿的空肠段在水中匀浆。对这些匀浆进行乳糖酶测定和蛋白质测定。乳糖注射组的乳糖酶值显著高于接受葡萄糖的胎儿组（表2），P小于0.0005。因此，胎儿晚期暴露于乳糖底物可增加胎儿肠道乳糖酶活性。
