Ultrasound contrast media and their use in obstetrics and gynecology.

Contrast media have gained acceptance to enhance ultrasonography in many fields of medicine; in particular, cardiology. Several agents have been described and many more are being manufactured and tested. By increasing the number of strong sound scatterers, these agents improve images by increasing the amount of echoes. This is true both for grey-scale and color or Doppler imaging. Their use in obstetrics is very limited at the moment because of safety issues. In a laboratory setup, they have been shown to markedly enhance placental imaging. In gynecology, imaging of the uterine cavity and Fallopian tubes is greatly improved. A potential area where ultrasound contrast may find a role is gynecological oncology. Vascularity is increased in many tumors, but usually vessel diameter is small and velocity low. One can therefore expect future use of the ultrasound contrast agents in ovarian or other gynecological neoplasms.