糖尿病肾病合并抗肾小球基底膜肾炎

Diabetic nephropathy with anti-GBM nephritis.

作者信息

Ahuja T S, Velasco A, Deiss W, Indrikovs A J, Rajaraman S

机构信息

Department of Medicine, University of Texas Medical Branch at Galveston 77555, USA.

出版信息

Am J Kidney Dis. 1998 Jan;31(1):127-30. doi: 10.1053/ajkd.1998.v31.pm9428463.

DOI:10.1053/ajkd.1998.v31.pm9428463

PMID:9428463

Abstract

Immune complex glomerulonephritis can be superimposed on diabetic glomerulosclerosis. Idiopathic membranous glomerulonephritis, immunoglobulin (Ig) A glomerulonephritis, Henoch-Schönlein nephritis, membranoproliferative glomerulonephritis, minimal change glomerulonephritis, postinfectious glomerulonephritis, lupus nephritis, amyloidosis, focal segmental glomerulosclerosis, and rarely crescentic glomerulonephritis can all occur with diabetic nephropathy. We describe for the first time an unusual case of diabetic nephropathy coexistent with anti-glomerular basement membrane (GBM) nephritis. The renal function of this patient improved with plasmapheresis and immunosuppressives. We also review the literature on coexistent rapidly progressive glomerulonephritis (RPGN) and diabetic nephropathy.

摘要

免疫复合物性肾小球肾炎可叠加于糖尿病肾小球硬化症之上。特发性膜性肾小球肾炎、免疫球蛋白（Ig）A 肾小球肾炎、过敏性紫癜性肾炎、膜增生性肾小球肾炎、微小病变性肾小球肾炎、感染后肾小球肾炎、狼疮性肾炎、淀粉样变性、局灶节段性肾小球硬化症，以及罕见的新月体性肾小球肾炎都可与糖尿病肾病同时发生。我们首次描述了一例糖尿病肾病合并抗肾小球基底膜（GBM）肾炎的不寻常病例。该患者的肾功能通过血浆置换和免疫抑制剂治疗得到改善。我们还回顾了关于同时存在快速进展性肾小球肾炎（RPGN）和糖尿病肾病的文献。