Kelly-Garcia J, Roman-Berumen J F, Ibarra-Perez C
Departamento de Cirugía Torácica, Hospital de Oncología, Instituto Mexicano del Seguro Social, México, D.F., México.
Arch Med Res. 1997 Winter;28(4):583-5.
The search for the ideal agent to achieve pleurodesis for malignant pleural effusions is still on. Twenty-two patients with dyspnea-producing, recurrent pleural effusions secondary to epithelial neoplasms were subjected to instillation into the pleural cavity of either iodopovidone (14 patients) or bleomycin (8 patients) through a large bore chest tube. The results showed that in 9 of the 14 patients receiving iodopovidone (64.2%) and in 7 of the 8 patients in the bleomycin group (87.5%) there was no further need for drainage of the pleural space. Local or systematic complications occurred in 8 patients; no complication was severe. In conclusion in this preliminary study, iodopovidone has shown promise as an effective, readily available and inexpensive alternative to achieve chemical pleurodesis in cases of recurrent, incapacitating effusions secondary to malignant epithelial neoplasms; further studies are needed to confirm these initial results.
寻找用于恶性胸腔积液胸膜固定术的理想药物的工作仍在继续。22例因上皮性肿瘤导致产生呼吸困难的复发性胸腔积液患者，通过大口径胸管将碘伏酮（14例患者）或博来霉素（8例患者）注入胸腔。结果显示，接受碘伏酮治疗的14例患者中有9例（64.2%），博来霉素组8例患者中有7例（87.5%）无需再进行胸腔引流。8例患者出现局部或全身并发症；均无严重并发症。总之，在这项初步研究中，碘伏酮已显示出有望成为一种有效、易于获得且廉价的替代品，用于在恶性上皮性肿瘤继发的复发性、使人衰弱的胸腔积液病例中实现化学性胸膜固定术；需要进一步研究来证实这些初步结果。
