Goethals P, Volders F, Van der Eycken J, van Eijkeren M, Lemahieu I, Dams R
Department of Analytical Chemistry, Institute for Nuclear Sciences, University of Gent, Belgium.
Nucl Med Biol. 1997 Nov;24(8):713-8. doi: 10.1016/s0969-8051(97)00110-8.
In this study, 6-methyl-2'-deoxyuridine, an artificial nucleoside, was labeled with 11C in the methyl position. Tissue distribution of 6-methyl[11C]-2'-deoxyuridine was investigated in normal Wistar rats and compared to the behavior of the natural nucleoside [methyl-11C]thymidine. High renal clearance, up to at least 20% of the injected activity, was noticed during the 20 min period following injection. Tissue distribution as determined by dynamic PET studies of both 11C-labeled nucleosides was significantly different for most of the organs.
