Vicini P, Manotti C, Caretta A, Amoretti L
Dipartimento Farmaceutico, Universita' di Parma, Italy.
Arzneimittelforschung. 1997 Nov;47(11):1218-21.
The synthesis of a new compound, 2-amino-1,2-benzisothiazolin-3-one, is described and its antiplatelet activity was studied. A good platelet aggregation inhibitory activity of the tested drug was clearly demonstrated both in vitro and ex vivo, presumably through an effect on arachidonic acid cascade or directly on thromboxane A2 (TXA2) receptors. An early and long lasting effect on bleeding time has also been observed. The results suggest that 2-amino-1,2-benzisothiazolin-3-one could be a potential antithrombotic agent.
描述了一种新化合物2-氨基-1,2-苯并异噻唑啉-3-酮的合成，并研究了其抗血小板活性。受试药物在体外和体内均表现出良好的血小板聚集抑制活性，推测其作用机制可能是通过影响花生四烯酸级联反应或直接作用于血栓素A2（TXA2）受体。还观察到该药物对出血时间有早期且持久的影响。结果表明，2-氨基-1,2-苯并异噻唑啉-3-酮可能是一种潜在的抗血栓药物。
