Meador K J, Baker G A
Department of Neurology, Medical College of Georgia, Augusta 30912-3280, USA.
J Child Neurol. 1997 Nov;12 Suppl 1:S44-7. doi: 10.1177/0883073897012001101.
Lamotrigine is a new antiepileptic drug that may possess unique cognitive and behavioral characteristics. Although lamotrigine can produce neurobehavioral toxicity, it is generally well tolerated. In one study directly comparing lamotrigine to placebo as add-on therapy in patients with intractable epilepsy, no objective cognitive effects were observed in a limited neuropsychological battery. Several studies have demonstrated favorable effects of lamotrigine on psychological well-being that were not explained by simple effects on seizure frequency and severity. In direct comparisons with carbamazepine and phenytoin, lamotrigine has been reported to produce positive effects on quality of life scales of patient perception. In addition, positive behavioral effects have also been observed in two blinded studies and several open trials for patients with severe mental disability and refractory epilepsy. Future studies with more extensive neuropsychological assessments are needed to delineate the differential cognitive and behavioral effects of lamotrigine in epilepsy and psychiatric disorders.
拉莫三嗪是一种新型抗癫痫药物，可能具有独特的认知和行为特征。虽然拉莫三嗪可产生神经行为毒性，但总体耐受性良好。在一项将拉莫三嗪与安慰剂作为难治性癫痫患者附加疗法的直接比较研究中，在有限的神经心理测试中未观察到客观的认知效应。多项研究表明，拉莫三嗪对心理健康有积极影响，而这并非单纯由对癫痫发作频率和严重程度的影响所解释。在与卡马西平和苯妥英钠的直接比较中，据报道拉莫三嗪对患者感知的生活质量量表产生了积极影响。此外，在两项针对重度智力残疾和难治性癫痫患者的双盲研究和多项开放试验中也观察到了积极的行为效应。需要进行更广泛神经心理评估的未来研究，以明确拉莫三嗪在癫痫和精神疾病中的不同认知和行为效应。
