Roman J M, Golub E S
J Exp Med. 1976 Mar 1;143(3):482-96. doi: 10.1084/jem.143.3.482.
Cells from the spleen, thymus, lymph node, and liver of leukemic AKR mice suppress in vitro antibody responses of normal syngeneic and semiallogeneic cells. This suppression can be mediated by irradiated leukemic cells, requires cell contact between leukemic and normal cells, and may occur at any time during the in vitro culture period. Leukemic AKR cells do not suppress antibody responses of allogeneic cells, even when allogeneic cells have H-2 or background genes homologous with AKR. Leukemic cells do, however, suppress cells that are unable to respond allogeneically to leukemic AKR cells, such as cells of the F1s of AKR. Suppression of normal AKR antibody responses by leukemic AKR cells may be overcome by addition of irradiated allogeneic cells. The fact that leukemic AKR cells are able to suppress normal lymphocyte responses may be of significance in pathogenesis of leukemia in these mice.
白血病AKR小鼠脾脏、胸腺、淋巴结和肝脏中的细胞可在体外抑制同基因正常细胞和半异基因细胞的抗体反应。这种抑制作用可由经辐照的白血病细胞介导，需要白血病细胞与正常细胞之间的细胞接触，并且可能在体外培养期间的任何时间发生。白血病AKR细胞不会抑制异基因细胞的抗体反应，即使异基因细胞具有与AKR同源的H-2或背景基因。然而，白血病细胞确实会抑制那些不能对白血病AKR细胞产生异基因反应的细胞，例如AKR品系杂交一代（F1）的细胞。添加经辐照的异基因细胞可克服白血病AKR细胞对正常AKR抗体反应的抑制。白血病AKR细胞能够抑制正常淋巴细胞反应这一事实可能对这些小鼠白血病的发病机制具有重要意义。
