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肉芽肿形成的过继性抑制

Adoptive suppression of granuloma formation.

作者信息

Colley D G

出版信息

J Exp Med. 1976 Mar 1;143(3):696-700. doi: 10.1084/jem.143.3.696.

DOI:10.1084/jem.143.3.696
PMID:942994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190146/
Abstract

Anti-egg granulomas formed in mice with chronic S. mansoni infection are smaller than those formed early (8 wk) after infection. Passive transfer of serum from mice with chronic infections to recipient mice with developing (6 wk) infections did not affect hepatic granuloma size at 8 wk of infection. In contrast, either spleen cells or lymph node cells from mice with chronic infections strongly suppressed the granulomatous process in recipient mice. Spleen cells, but not lymph node cells, of early-(7 wk) infected mice exhibited some ability to diminish granuloma formation in recipients. It appeared that the use of two sequential, weekly passive transfers of spleen or lymph node cells from chronic mice was even more effective in this suppressive capacity than a single transfer.

摘要

慢性曼氏血吸虫感染小鼠形成的抗卵肉芽肿比感染早期（8周）形成的肉芽肿小。将慢性感染小鼠的血清被动转移到正在发展感染（6周）的受体小鼠中，在感染8周时不影响肝脏肉芽肿的大小。相比之下，慢性感染小鼠的脾细胞或淋巴结细胞强烈抑制受体小鼠的肉芽肿形成过程。早期（7周）感染小鼠的脾细胞而非淋巴结细胞表现出一定能力来减少受体小鼠中的肉芽肿形成。似乎每周连续两次被动转移慢性感染小鼠的脾细胞或淋巴结细胞在这种抑制能力上比单次转移更有效。

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本文引用的文献

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Immunological enhancement: a study of blocking antibodies.免疫增强：封闭抗体的研究
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Intradermal immune responses to a schistosomal egg antigen during experimental murine Schistosoma mansoni infection.实验性小鼠曼氏血吸虫感染期间对血吸虫卵抗原的皮内免疫反应
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