Prenatal diagnosis of total anomalous pulmonary venous connection with asplenia.

The prenatal diagnosis of 2 fetuses with total anomalous pulmonary venous connection was made by color Doppler echocardiography at 31 and 38 weeks of gestation, respectively. Both had asplenic hearts and their diagnoses were confirmed by postnatal echocardiography, magnetic resonance imaging, and angiography. The antenatal diagnosis of total anomalous pulmonary venous connection in right isomerism could provide an optimal postnatal medical and surgical management. Moreover, monitoring of the velocity profile of the pulmonary venous flow is beneficial for decreasing the risk of sudden collapse by pulmonary venous obstruction throughout the perinatal period.