Campbell J J, Hedrick J, Zlotnik A, Siani M A, Thompson D A, Butcher E C
Laboratory of Immunology and Vascular Biology, Department of Pathology, and Digestive Disease Center, Department of Medicine, Stanford University Medical School, Stanford, CA 94305, USA.
Science. 1998 Jan 16;279(5349):381-4. doi: 10.1126/science.279.5349.381.
Circulating lymphocytes are recruited from the blood to the tissue by rolling along the endothelium until being stopped by a signaling event linked to the Gialpha subunit of a heterotrimeric GTP-binding protein; that event then triggers rapid integrin-dependent adhesion. Four chemokines are now shown to induce such adhesion to intercellular adhesion molecule-1 and to induce arrest of rolling cells within 1 second under flow conditions similar to those of blood. SDF-1 (also called PBSF), 6-C-kine (also called Exodus-2), and MIP-3beta (also called ELC or Exodus-3) induced adhesion of most circulating lymphocytes, including most CD4+ T cells; and MIP-3alpha (also called LARC or Exodus-1) triggered adhesion of memory, but not naïve, CD4+ T cells. Thus, chemokines can regulate the arrest of lymphocyte subsets under flowing conditions, which may allow them to control lymphocyte-endothelial cell recognition and lymphocyte recruitment in vivo.
循环淋巴细胞通过沿内皮滚动从血液被募集到组织中，直到被与异源三聚体GTP结合蛋白的Gialpha亚基相关的信号事件所阻止；该事件随后触发快速的整合素依赖性黏附。现在发现四种趋化因子可诱导对细胞间黏附分子-1的这种黏附，并在类似于血液流动的条件下在1秒内诱导滚动细胞的停滞。SDF-1（也称为PBSF）、6-C-趋化因子（也称为Exodus-2）和MIP-3β（也称为ELC或Exodus-3）诱导大多数循环淋巴细胞的黏附，包括大多数CD4+ T细胞；而MIP-3α（也称为LARC或Exodus-1）触发记忆性而非初始CD4+ T细胞的黏附。因此，趋化因子可在流动条件下调节淋巴细胞亚群的停滞，这可能使它们能够在体内控制淋巴细胞-内皮细胞识别和淋巴细胞募集。
