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[健康受试者输注低分子羟乙基淀粉(万汶)后血液粘度的改善]

[Improvement of blood viscosity after infusion of low-molecular hydroxyethyl starch (Expafusin) in healthy subjects].

作者信息

Ehrly A M, Landgraf H, Saeger-Lorenz K, Hasse S

出版信息

Infusionsther Klin Ernahr. 1979 Dec;6(6):331-6.

PMID:94316
Abstract

In healthy volunteers, 500 ml of a 6% low molecular weight hydroxyethyl starch solution (Expafusin) was infused intravenously within 30 minutes. Blood samples for the measurement of rheological parameters were obtained before and after the infusion. Blood and plasma viscosity were significantly decreased after the infusion of HES. Red cell deformability as measured by a filtration technique was slightly improved. Red cell aggregation as measured by a light transmission method was markedly reduced. Repeated infusion of 500 ml Expafusin indicates that the improvement of the flow properties of blood can be maintained for more than 3 hours.

摘要

在健康志愿者中,30分钟内静脉输注500毫升6%的低分子质量羟乙基淀粉溶液(贺斯)。在输注前后采集血样以测量流变学参数。输注羟乙基淀粉后,血液和血浆黏度显著降低。通过过滤技术测量的红细胞变形性略有改善。通过光透射法测量的红细胞聚集明显减少。重复输注500毫升贺斯表明血液流动特性的改善可维持3小时以上。

相似文献

1
[Improvement of blood viscosity after infusion of low-molecular hydroxyethyl starch (Expafusin) in healthy subjects].[健康受试者输注低分子羟乙基淀粉(万汶)后血液粘度的改善]
Infusionsther Klin Ernahr. 1979 Dec;6(6):331-6.
2
[Improvement of the flow properties of the blood of patients by low-molecular hydroxyethyl starch (Expafusin)].
Infusionsther Klin Ernahr. 1982 Aug;9(4):202-6.
3
[Effect of an infusion with middle molecular weight hydroxyethyl starch (HAES-steril 10%) on the flow properties of blood in healthy probands].
Infusionsther Klin Ernahr. 1981 Aug;8(4):200-4.
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[Hemorheologic, micro- and macrocirculatory effects of hypervolemic infusions of middle molecular weight hydroxyethyl starch (10%, 200,000/0.62) in healthy probands].
Infusionsther Klin Ernahr. 1987 Oct;14(5):233-8.
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[Hemorheologic and circulatory effects of hemodilution with medium molecular weight hydroxyethyl starch in two concentrations (HAES 200/0.62 10% and 6%)].
Acta Med Austriaca. 1991;18 Suppl 1:9-15.
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[Comparison of 2 6% middle-molecular hydroxyethyl starch solutions on elimination kinetics and flow characteristics of blood in volunteers].[两种6%中分子羟乙基淀粉溶液对志愿者血液清除动力学和血流特性的比较]
Infusionsther Transfusionsmed. 1994 Aug;21(4):251-9.
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[Hemorheologic, micro- and macrocirculatory effects of an infusion of 500 ml of 6% medium molecular weight hydroxyethyl starch (Haes 200,000/0.5)].
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In vitro effects of polyethylene glycol in University of Wisconsin preservation solution on human red blood cell aggregation and hemorheology.聚乙二醇在威斯康星大学保存液中对人红细胞聚集和血液流变学的体外影响。
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引用本文的文献

1
[Comparative study of low molecular dextran or hydroxyethyl starch as a volume substitute in hemodilution therapy].
Klin Wochenschr. 1986 Jan 2;64(1):29-37. doi: 10.1007/BF01721578.