年龄和性别对小脑半球及蚓部的不同影响：一项前瞻性磁共振成像研究
Differential effects of age and sex on the cerebellar hemispheres and the vermis: a prospective MR study.
作者信息
Raz N, Dupuis J H, Briggs S D, McGavran C, Acker J D
机构信息
Department of Psychology, University of Memphis, Tenn 38152, USA.
出版信息
AJNR Am J Neuroradiol. 1998 Jan;19(1):65-71.
PURPOSE
The purpose of this study was to determine the effects of age and sex on the size of the cerebellar hemispheres, the cerebellar vermis, and the pons in healthy adults.
METHODS
We estimated the volumes of the cerebellar hemispheres (excluding the vermis and the peduncles), the cross-sectional area of the vermis, and the cross-sectional area of the ventral pons from MR images obtained in 146 healthy volunteers, 18 to 77 years old.
RESULTS
We found a mild but significant age-related reduction in the volume of the cerebellar hemispheres and in the total area of the cerebellar vermis; however, the analysis of age trends in the vermian lobules revealed differential age-related declines. The areas of lobules VI and VII and of the posterior vermian lobules (VIII-X) declined significantly with age, whereas the anterior vermis (I-V) showed no significant age-related shrinkage. The volume of the cerebellar hemispheres (especially the right) and the area of the anterior vermis were greater in men, even after adjustment for height. Neither age nor sex affected the area of the ventral pons.
CONCLUSIONS
Normal aging of the cerebellum is associated with selective regional shrinkage. The cerebellar hemispheres and the area of the anterior vermis may be larger in men than in women regardless of differences in body size.
目的
本研究旨在确定年龄和性别对健康成年人小脑半球、小脑蚓部和脑桥大小的影响。
方法
我们从146名年龄在18至77岁的健康志愿者的磁共振图像中估计了小脑半球（不包括蚓部和脚）的体积、蚓部的横截面积以及腹侧脑桥的横截面积。
结果
我们发现小脑半球体积和小脑蚓部总面积存在轻度但显著的与年龄相关的减小；然而，对蚓小叶年龄趋势的分析显示出与年龄相关的不同程度下降。小叶VI和VII以及蚓部后小叶（VIII - X）的面积随年龄显著下降，而蚓部前叶（I - V）未显示出与年龄相关的显著萎缩。即使在对身高进行调整后，男性的小脑半球体积（尤其是右侧）和蚓部前叶面积仍大于女性。年龄和性别均不影响腹侧脑桥的面积。
结论
小脑的正常老化与选择性区域萎缩有关。无论体型差异如何，男性的小脑半球和蚓部前叶面积可能大于女性。
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