丁胺卡那霉素的1-N-烷基类似物。
1-N-Alkyl analogs of butirosin.
作者信息
Hayashi T, Saeki H, Takeda N, Ohko E
出版信息
J Antibiot (Tokyo). 1979 Dec;32(12):1280-7. doi: 10.7164/antibiotics.32.1280.
PMID:94324
Abstract
Butirosin (Ia), 5''-amino-5''-deoxy-(Ic), 3',4'-dideoxy-(Ie), and 5''-amino-3',4',5''-trideoxy-butirosin A (If) were converted into the corresponding 1'''-deoxo derivatives, Ib, Id, Ig, and Ih by borane reduction. In addition, xylostasin (IIIa) was converted into its 1-N-ethyl derivative (IIIb) by reductive ethylation. Their antibacterial activities were discussed.
摘要
通过硼烷还原，将布替罗星（Ia）、5''-氨基-5''-脱氧布替罗星（Ic）、3',4'-二脱氧布替罗星（Ie）和5''-氨基-3',4',5''-三脱氧布替罗星A（If）转化为相应的1'''-脱氧衍生物，即Ib、Id、Ig和Ih。此外，通过还原乙基化反应，将木糖抑素（IIIa）转化为其1-N-乙基衍生物（IIIb）。并对它们的抗菌活性进行了讨论。
相似文献
1
1-N-Alkyl analogs of butirosin.丁胺卡那霉素的1-N-烷基类似物。
J Antibiot (Tokyo). 1979 Dec;32(12):1280-7. doi: 10.7164/antibiotics.32.1280.
2
Chemical modification of aminoglycoside antibiotics. Some N-alkyl derivatives of sorbistin A1 (P-2563 P) and butirosin A.
Chem Pharm Bull (Tokyo). 1979 Jan;27(1):65-75. doi: 10.1248/cpb.27.65.
3
5"-Amino-3',4',5"-trideoxybutirosin A, a new semisynthetic aminoglycoside antibiotic.5”-氨基-3',4',5”-三脱氧丁胺卡那霉素A，一种新型半合成氨基糖苷类抗生素。
J Antibiot (Tokyo). 1975 Jul;28(7):522-9. doi: 10.7164/antibiotics.28.522.
4
Synthesis of aminotrideoxybutirosin A, a chemically modified antibiotic active against butirosin-resistant bacteria.氨基去氧丁胺卡那霉素A的合成，一种对丁胺卡那霉素耐药菌有效的化学修饰抗生素。
J Antibiot (Tokyo). 1975 Jul;28(7):530-6. doi: 10.7164/antibiotics.28.530.
5
Synthesis of 3', 3''-dideoxy-butirosin.3',3''-二脱氧布替罗星的合成
J Antibiot (Tokyo). 1978 Sep;31(9):933-5. doi: 10.7164/antibiotics.31.933.
6
Mutational biosynthesis of butirosin analogs. II. 3', 4'-Dideoxy-6'-N-methylbutirosins, new semisynthetic aminoglycosides.
J Antibiot (Tokyo). 1978 Oct;31(10):1031-8. doi: 10.7164/antibiotics.31.1031.
7
Mutational biosynthesis of butirosin analogs. III. 6'-N-methylbutirosins and 3', 4'-dideoxy-6'-c-methylbutirosins, new semisynthetic aminoglycosides.
J Antibiot (Tokyo). 1978 Oct;31(10):1039-45. doi: 10.7164/antibiotics.31.1039.
8
A new methods for the 3'-deoxygenation of butirosins A and B.一种用于巴龙霉素A和B 3'-脱氧的新方法。
Carbohydr Res. 1978 Feb;60(2):289-302. doi: 10.1016/s0008-6215(78)80036-6.
9
Synthesis and activity of butirosin derivatives with 5''-amidino and 5''-guanidino substituents.具有5''-脒基和5''-胍基取代基的布替罗星衍生物的合成与活性
J Antibiot (Tokyo). 1991 Jan;44(1):86-92. doi: 10.7164/antibiotics.44.86.
10
Mutational biosynthesis of butirosin analogs.布替罗星类似物的突变生物合成。
J Antibiot (Tokyo). 1978 Mar;31(3):247-9. doi: 10.7164/antibiotics.31.247.
引用本文的文献
1
Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics.4,5-氨基糖苷类抗生素 5' 位修饰物的结构-活性关系。
ChemMedChem. 2022 Jul 5;17(13):e202200120. doi: 10.1002/cmdc.202200120. Epub 2022 Apr 22.
Zotero 插件