Johns A, Paton D M
Eur J Pharmacol. 1976 Jan;35(1):145-50. doi: 10.1016/0014-2999(76)90309-5.
The effects of 2 mM RbCl on adrenergic transmission in rabbit vas deferens were investigated. Rubidium, but not potassium, markedly potentiated the sustained, secondary contractile response to transmural stimulation at 2--16 Hz. This effect was not abolished by indomethacin. Significant spontaneous desensitization to (--)-noradrenaline occurred, but this was prevented by the addition of 2 mM RbCl or KCl. Addition of 2 mM RbCl, but not of 2 mM KCl, significantly increased the amount of [3H] (+/-)-metaraminol released on transmural stimulation at 5 Hz, without affecting the uptake of [3H] (+/-)-metaraminol over a 30 min period. It is suggested that rubidium mainly potentiated responses of rabbit vas deferens to transmural stimulation by increasing transmitter release, possibly as a result of prolongation of the action potential.
研究了2 mM氯化铷对兔输精管肾上腺素能传递的影响。铷而非钾能显著增强在2 - 16 Hz经壁刺激下的持续性继发性收缩反应。吲哚美辛不能消除这种作用。对（-）-去甲肾上腺素出现了显著的自发脱敏现象，但加入2 mM氯化铷或氯化钾可防止这种情况。加入2 mM氯化铷而非2 mM氯化钾，能显著增加在5 Hz经壁刺激时释放的[3H]（±）-间羟胺量，且在30分钟内不影响[3H]（±）-间羟胺的摄取。提示铷主要通过增加递质释放来增强兔输精管对经壁刺激的反应，这可能是动作电位延长的结果。
