Cetin M, Gürgey A, Gümrük F, Altay C
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 1997 Oct-Dec;39(4):459-64.
Serum erythropoietin (EPO) levels were determined in 30 children with iron deficiency anemia. The mean age of the children, hemoglobin (Hb) levels, serum EPO levels and log EPO values were 4.7 +/- 5 years, 6.7 +/- 1.7 g/dl, 2284 +/- 3177 mU/ml and 2.81 +/- 0.82, respectively. In 83 percent of the patients poor diet was the determined cause of iron deficiency and in the remaining 17 percent, chronic blood loss. A significant negative correlation was found between the log EPO values and Hb values (r = 0.62, p < 0.01). There was no significant correlation between log EPO values and the other parameters [sex, age, mean corpuscular volume (MCV) red blood cell (RBC) red cell distribution width (RDW), serum iron, iron binding capacity]. There was a significant difference in the age of the patients with an Hb value < 5.5 g/dl and those with a value > or = 5.5 Significant differences were also observed in log EPO levels among these patients (p < 0.004). The mean Hb value of patients with log EPO values > or = 3 was lower than that in patients with log EPO values < 3 (p < 0.003). In 20 percent of the patients, serum EPO levels were much lower than the values expected from their Hb level. Serum EPO levels were high in all five patients with a history of chronic blood loss.
对30名缺铁性贫血儿童测定了血清促红细胞生成素（EPO）水平。这些儿童的平均年龄、血红蛋白（Hb）水平、血清EPO水平及EPO对数值分别为4.7±5岁、6.7±1.7g/dl、2284±3177mU/ml和2.81±0.82。83%的患者缺铁的确定原因是饮食不佳，其余17%是慢性失血。EPO对数值与Hb值之间存在显著负相关（r = 0.62，p < 0.01）。EPO对数值与其他参数[性别、年龄、平均红细胞体积（MCV）、红细胞（RBC）、红细胞分布宽度（RDW）、血清铁、铁结合能力]之间无显著相关性。Hb值<5.5g/dl的患者与Hb值≥5.5g/dl的患者在年龄上存在显著差异。这些患者的EPO对数值之间也观察到显著差异（p < 0.004）。EPO对数值≥3的患者的平均Hb值低于EPO对数值<3的患者（p < 0.003）。20%的患者血清EPO水平远低于根据其Hb水平预期的值。所有5名有慢性失血史的患者血清EPO水平均较高。
