Zhaugasheva S K
Farmakol Toksikol. 1976 Jan-Feb;39(1):50-3.
Through local stimulation of various structures of medulla oblongata a centrogenic bronchial spasm was simulated in acute tests on cats. A peripheral bronchial spasm was reporduced by stimulating the peripheral length of the vagus. An experimental bronchial spasm caused by activation of reticular nuclei and of a single fascicular nucleus halidor suppressed with doses half as large as the ones needed to inhibit the peripheral spasm. An application of halidor to the ground of the fourth ventricle tended to immediately lessen the intensity of the bronchial spasm, this suggesting a central component in the action of the drug.
在对猫进行的急性试验中,通过对延髓的各种结构进行局部刺激,模拟了中枢性支气管痉挛。通过刺激迷走神经的外周段诱发外周支气管痉挛。由网状核和单个束状核激活引起的实验性支气管痉挛,抑制所需剂量仅为抑制外周痉挛所需剂量的一半。将哈利多(halidor)应用于第四脑室底部往往会立即减轻支气管痉挛的强度,这表明该药物的作用存在中枢成分。