Isotani H, Fukumoto Y, Kawamura H, Sasada M, Hattori K, Fujiwara T, Kobayashi Y
Department of Internal Medicine, Hirakata City Hospital, Osaka, Japan.
Ann Hematol. 1997 Nov-Dec;75(5-6):243-6. doi: 10.1007/s002770050351.
A 24-year-old woman with osteomyelitis was diagnosed as having p47-phox-deficient chronic granulomatous disease (CGD). The patient showed a marked deficiency of p47-phox, which is very rare in Japan. As the clinical response to various antibiotics including sulfamethoxazole-trimethoprim was not satisfactory, we added recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the treatment protocol. We report the beneficial clinical course of the patient, together with the effect of rhG-CSF on the granulocyte function, and the present report indicates that rhG-CSF is useful for the treatment of antibiotic-resistant infection in the variant type of p47-phox-defective CGD.
