Krause I, Shraga I, Molad Y, Guedj D, Weinberger A
Department of Medicine B, Rabin Medical Center, Petah-Tiqva, Israel.
Scand J Rheumatol. 1997;26(6):435-9. doi: 10.3109/03009749709065715.
Patients with systemic lupus erythematosus (SLE) were evaluated using a telephone questionnaire on the activity of various disease manifestations during the seasons of the past year. The results were compared to those of patients with Behcet's disease (BD), using the same questionnaires, and analyzed in relation to the mean temperature, humidity, barometric pressure, and ultraviolet radiation (UVR) in the patient's location, obtained from the official Israeli Meteorological Service. It was found that SLE patients had a tendency towards winter worsening of clinical manifestations, shown as increased incidence of joint pains, weakness, fatigue, Raynaud's phenomenon, and rash, as well as increased number of hospital admissions, sick leaves, and need to raise the dose of medications. The symptoms of patients with BD were not correlated to seasons of the year, except for increased joint pains in autumn and spring. We suggest that UVR accumulation might cause exacerbations in SLE patients several months after prolonged exposure to sunlight in the summer.
通过电话问卷对系统性红斑狼疮（SLE）患者过去一年各季节各种疾病表现的活动情况进行了评估。使用相同问卷将结果与白塞病（BD）患者的结果进行比较，并根据从以色列官方气象服务机构获得的患者所在地的平均温度、湿度、气压和紫外线辐射（UVR）进行分析。结果发现，SLE患者存在临床表现冬季加重的倾向，表现为关节疼痛、虚弱、疲劳、雷诺现象和皮疹的发生率增加，以及住院次数、病假天数增加和需要增加药物剂量。BD患者的症状与一年中的季节无关，除了秋季和春季关节疼痛增加。我们认为，紫外线辐射积累可能在夏季长时间暴露于阳光下数月后导致SLE患者病情加重。
