Schnell A H, Karunaratne P M, Witte J S, Dawson D V, Elston R C
Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, Ohio 44109, USA.
Genet Epidemiol. 1997;14(6):675-80. doi: 10.1002/(SICI)1098-2272(1997)14:6<675::AID-GEPI21>3.0.CO;2-M.
We applied regressive modeling to the data described by Stine et al. [1995] and further explored the possible linkage of bipolar disorder to marker D18S41 on chromosome 18. We performed analyses to determine age-dependent penetrance functions that best fit the data and that allow for residual familial correlations. Specifically, we introduce here a simple method to allow for a sibling correlations. that is not due to segregation at the linked locus, and then extend the results of Stine et al. [1995] by using the best fitting "regressive" model of this kind as input into a lod score linkage analysis. Although a formal segregation analysis was not attempted, a surprising finding was that, except for doubtful linkage to D18S41, there is little evidence for genetic transmission of bipolar disorder in these families.
我们对Stine等人[1995年]所描述的数据应用了回归模型，并进一步探究双相情感障碍与18号染色体上标记D18S41之间可能的联系。我们进行了分析，以确定最符合数据且考虑了家族残余相关性的年龄依赖性外显率函数。具体而言，我们在此介绍一种简单方法，以考虑同胞相关性，这种相关性并非由连锁基因座的分离所致，然后通过将这种最佳拟合的“回归”模型的结果作为输入，用于对数优势计分连锁分析，扩展了Stine等人[1995年]的研究结果。尽管未尝试进行正式的分离分析，但一个惊人的发现是，除了与D18S41存在可疑的连锁关系外，这些家族中几乎没有证据表明双相情感障碍存在遗传传递。
