Probabilistic diagnosis in linkage analysis of bipolar disorder: putting weights on the fringe.
作者信息
Van Eerdewegh P, Santangelo S L, Lee H, Laird N M, Blacker D
机构信息
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
出版信息
Genet Epidemiol. 1997;14(6):693-8. doi: 10.1002/(SICI)1098-2272(1997)14:6<693::AID-GEPI24>3.0.CO;2-K.
Abstract
We explored the utility of probabilistic weighting of fringe phenotypes in linkage analysis of bipolar disorder for the GAW10 chromosome 18 data. Four liability classes were assigned probabilistic weights based on the estimated probability that the case was a true bipolar. The weights were incorporated in parametric and nonparametric, single and multipoint analyses.
摘要
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