中性粒细胞弹性蛋白酶抑制剂（ONO-5046.Na）可抑制胰腺癌细胞系Capan-1的增殖、运动性和趋化性。
Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1.
作者信息
Kamohara H, Sakamoto K, Mita S, An X Y, Ogawa M
机构信息
Department of Surgery II, Kumamoto University School of Medicine, Japan.
出版信息
Res Commun Mol Pathol Pharmacol. 1997 Oct;98(1):103-8.
ONO-5046. Na is a specific neutrophil elastase inhibitor. We investigated the in vitro effect of ONO-5046. Na on the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line (Capan-1, well differentiated adenocarcinoma). ONO-5046. Na significantly suppressed the proliferation, motility and chemotaxis at a concentration of more than 100, 10 and 1 microgram/ml of ONO-5040. Na, respectively (p < 0.005, p < 0.05 and p < 0.05, respectively). These results indicate that ONO-5046. Na may have a role in preventing the progression and metastasis of pancreatic carcinoma cells, suggesting that ONO-5046. Na may serve as an anti-cancer agent.
ONO - 5046钠是一种特异性中性粒细胞弹性蛋白酶抑制剂。我们研究了ONO - 5046钠对胰腺癌细胞系（Capan - 1，高分化腺癌）增殖、运动和趋化性的体外作用。ONO - 5046钠在浓度分别超过100、10和1微克/毫升时，能显著抑制增殖、运动和趋化性（分别为p < 0.005、p < 0.05和p < 0.05）。这些结果表明，ONO - 5046钠可能在预防胰腺癌细胞的进展和转移中发挥作用，提示ONO - 5046钠可能作为一种抗癌剂。
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