Steinberg T, Rachmel A, Samra Z, Ashkenazi S
Department of Pediatrics, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
Isr J Med Sci. 1997 Nov;33(11):757-9.
Penicillin-resistant Streptococcus pneumoniae (PRP) is of worldwide concern. Treatment failures and fatalities of meningitis caused by PRP have been reported in other locations but not yet in Israel. We describe an 11-month-old infant with meningitis caused by PRP who failed to respond to initial treatment with cefotaxime. Vancomycin treatment caused a prompt cure. The minimal inhibitory concentrations of the isolate to penicillin, cefuroxime and cefotaxime were 1.0, 4.0 and 1.0 micrograms/ml, respectively. New guidelines for the treatment of meningitis in Israel are suggested.
耐青霉素肺炎链球菌（PRP）已引起全球关注。其他地区已报告了由PRP引起的脑膜炎治疗失败和死亡病例，但以色列尚未有此类报告。我们描述了一名11个月大的婴儿，他患有由PRP引起的脑膜炎，对头孢噻肟的初始治疗没有反应。万古霉素治疗迅速治愈了该患儿。该分离株对青霉素、头孢呋辛和头孢噻肟的最低抑菌浓度分别为1.0、4.0和1.0微克/毫升。我们建议了以色列脑膜炎治疗的新指南。
