Ford J H
Genetic Consulting and Testing (G.C.A.T) Pty Ltd., Port Adelaide, Australia.
Mutat Res. 1997 Dec 12;396(1-2):195-203. doi: 10.1016/s0027-5107(97)00184-x.
The following questions are addressed: (A) What are aneuploidogens and how do they act? (B) Is there any evidence that aneuploidy per se causes malformations? (C) What examples are there of abnormalities, apparently attributable to aneuploidogens acting as teratogens? (D) Do abnormalities of cell division cause both teratogenesis and aneuploidy? Considerable research has addressed question (A), but there is little which addresses the other three questions. The question of whether aneuploidy per se causes malformations remains open. Some suggestions for further research are made.
（A）非整倍体诱变剂是什么，它们如何起作用？（B）是否有证据表明非整倍体本身会导致畸形？（C）有哪些异常情况明显可归因于作为致畸剂的非整倍体诱变剂？（D）细胞分裂异常是否会导致致畸和非整倍体？大量研究探讨了问题（A），但针对其他三个问题的研究较少。非整倍体本身是否会导致畸形的问题仍未解决。本文提出了一些进一步研究的建议。
