[骨质疏松症的动物模型]

[Animal models of osteoporosis].

作者信息

da Paz L H, Jorgetti V, Yoshinari N H

机构信息

Disciplina de Reumatologia, Faculdade de Medicina, Universidade de São Paulo.

出版信息

Rev Hosp Clin Fac Med Sao Paulo. 1997 Mar-Apr;52(2):86-9.

PMID:9435401

Abstract

The authors review the literature regarding the animal models of osteoporosis in two main groups: The resorption-dominant models (oovariectomy, orchiectomy, limbs imobilization, calcium restriction and use of hormonies) and another group, the formation-deficit models (senil rats, SAM mouse, glucocorticoid administration or limbs imobilization.

摘要

作者回顾了有关骨质疏松症动物模型的文献，主要分为两大类：以吸收为主的模型（卵巢切除、睾丸切除、肢体固定、钙限制和激素使用），以及另一类形成缺陷模型（老年大鼠、SAM小鼠、糖皮质激素给药或肢体固定）。